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杨崇林

发布时间:2018年03月27日        点击量:

 

杨崇林,男,1967年生,云南大学生命科学学院院长,云南大学生命科学研究中心主任,博士,博士生    导师。

教育与研究经历:

1998年于北京大学获博士学位。

1998-1999年为意大利International school for advanced studies分子神经生物学实验室访问学者。

1999-2005年先后在University of Maryland School of Medicine和University of Colorado从事博士后研究。

2006年入选中国科学院 "百人计划",终期获评优秀。

2010年获国家杰出青年基金资助。2013年被中国科协授予“全国优秀科技工作者”荣誉称号。2017年入选“国家百千万人才工程”。

杨崇林教授长期以来致力于探索以溶酶体为中心的重要细胞生物学问题,在溶酶体介导的凋亡细胞降解、内吞体-溶酶体运输、溶酶体发生的调控机制等领域取得突破性进展。他首次揭示了在进化上保守的凋亡细胞吞噬受体CED-1的偱环机制及其介导的细胞骨架重排的信号传导机制。杨崇林教授发现了多个在进化上保守的调控内吞体-溶酶体运输的新基因,并系统地揭示了它们在早-晚期内吞体转换及溶酶体运输中的作用机制。运用化学生物学研究方法,他发现了溶酶体发生的新的信号传导和调控机制,为以促进溶酶体发生为基础的神经退行性疾病的治疗提供了重要理论依据。这些出色的研究成果分别发表在包括Science, Nature Cell Biology, Journal of Cell Biology, Cell Research, PLoS Genetics等在内的重要国际学术期刊上,在国际学术界引起了广泛的反响。

   

近年来发表的主要代表性论著包括:

1.      Kai Liu, Ruxiao Xing, Youli Jian, Zhiyang Gao, Xinli Ma, Xiaojuan Sun, Yang Li, Meng Xu, Xin Wang, Yudong Jing, Weixiang Guo and Chonglin Yang. (2017). WDR91 is a Rab7 effector required for neuronal development. The Journal of Cell Biology. 216(10): 3307-3321.

2.      Jianhua Yin, Yaling Huang, Pengfei Guo, Siqi Hu, Sawako Yoshina, Nan Xuan, Qiwen Gan, Shohei Mitani, Chonglin Yang, Xiaochen Wang. (2017). GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans. The Journal of Cell Biology. (Online, DOI: 10.1083/jcb.201610001)

3.      Chonglin Yang, Xiaochen Wang. (2017). Cell Biology in China: Focusing on the Lysosome. Traffic, DOI: 10.1111/tra.12483 | Published Mar 30, 2017.

4.      Xuezhao Liu, Yang Li, Xin Wang, Ruxiao Xing, Kai Liu, Qiwen Gan, Changyong Tang, Zhiyang Gao, Youli Jian, Shouqing Luo, Weixiang Guo, and Chonglin Yang. (2017). The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy, The Journal of Cell Biology, DOI: 10.1083/jcb.201608039 | Published April 12, 2017.

5.      Shiya Cheng, Kai Liu, Chonglin Yang, Xiaochen Wang. (2017). Dissecting Phagocytic Removal of Apoptotic Cells in Caenorhabditis elegans. Methods in Molecular Biology: Phagocytosis and Phagosomes (Eds. Roberto Botelho ), Springer New York, 1519: 265-284. Print ISBN: 978-1-4939-6579-3.

6.      Yuan Li, Baohui Chen, Wei Zou, Xin Wang, Yanwei Wu, Dongfeng Zhao, Yanan Sun, Yubing Liu, Lianwan 5. Chen, Long Miao, Chonglin Yang, Xiaochen Wang. (2016). The lysosomal membrane protein SCAV-3 maintains lysosome integrity and adult longevity. The Journal of Cell Biology 215(2), 167-185.

7.      Yang Li, Meng Xu, Xiao Ding, Chen Yan, Zhiqin Song, Lianwan Chen, Xiahe Huang, XinWang,Youli Jian, Guihua Tang, Changyong Tang, Yingtong Di, Shuzhen Mu, Xuezhao Liu, Kai Liu, Ting Li,Yingchun Wang, Long Miao, Weixiang Guo, Xiaojiang Hao and Chonglin Yang. (2016). Protein kinase C controls lysosome biogenesis independently of mTORC1. Nature Cell Biology 18, 1065-1077.

8.      Xiaochen Wang, Chonglin Yang. (2016). Programmed cell death and clearance of cell corpses in Caenorhabditis elegans. Cellular and Molecular Life Sciences 73, 2221-2236.

9.      Kai Liu, Youli Jian, Xiaojuan Sun,Chengkui Yang,Zhiyang Gao, Zhili Zhang, Xuezhao Liu,Yang Li,Jing Xu,Yudong Jing,Shohei Mitani,Sudan He, Chonglin Yang. (2016). Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion. The Journal of Cell Biology 212(2), 181-198.

10. Meng Xu, Yubing Liu, Liyuan Zhao, Qiwen Gan, Xiaochen Wang, and Chonglin Yang. (2014). The lysosomal cathepsin protease CPL-1 plays a leading role in phagosomal degradation of apoptotic cells in Caenorhabditis elegans. Molecular Biology of the Cell 25, 2071-2083.

11. Didi Chen, Youli Jian, Xuezhao Liu, Yuanya Zhang, Jingjing Liang, Xiaying Qi, Hongwei Du, Wei Zou, Lianwan Chen, Yongping Chai, Guangshuo Ou, Long Miao, Yingchun Wang, and Chonglin Yang. (2013). Clathrin and AP2 are required for phagocytic receptor-mediated apoptotic cell clearance in Caenorhabditis elegans. PLoS Genetics 9(5), e1003517.

12. Jing Xu, Xiaojuan Sun, Yudong Jing, Mo Wang, Kai Liu, Youli Jian, Mei Yang, Zhukuan Cheng, Chonglin Yang. (2012). MRG-1 is required for genomic integrity in Caenorhabditis elegans germ cells. Cell Research 22, 886-902.

13. Didi Chen, Hui Xiao, Kai Zhang, Bin Wang,Zhiyang Gao, Youli Jian, Xiaying Qi, Jianwei Sun, Long Miao, Chonglin Yang. (2010). Retromer Is Required for Apoptotic Cell Clearance by Phagocytic Receptor Recycling. Science 327, 1261-1264.

14. Qinfang Shen, Fengsong Qin, Zhiyang Gao, Jie Cui, Hui Xiao, Zhiheng Xu, and Chonglin Yang. (2009). Adenine Nucleotide Translocator Cooperates with Core Cell Death Machinery to Promote Apoptosis in Caenorhabditis elegans. Molecular and Cellular Biology 29, 3881-3893.

15. Mei Yang, Jianwei Sun, Xiaojuan Sun, Qinfang Shen, Zhiyang Gao, Chonglin Yang. (2009). Caenorhabditis elegans Protein Arginine Methyltransferase PRMT-5 Negatively Regulates DNA Damage-Induced Apoptosis. PLoS Genetics 5(6), e1000514.

16. Hui Xiao, Didi Chen, Zhou Fang, Xiaojuan Sun, Jing Xu, Song Song, Jiajia Liu and Chonglin Yang. (2009). Lysosome biogenesis mediated by vps-18 affects apoptotic cell degradation in Caenorhabditis elegans. Molecular Biology of the Cell 20, 21-32.

17. Youli Jian, Zhiyang Gao, Jianwei Sun, Qinfang Shen, Feng Feng,Yudong Jing and Chonglin Yang. (2009). RNA aptamers interfering with nucleophosmin oligomerization induce apoptosis of cancer cells. Oncogene 28, 4201-4211.

18. Chonglin Yang, Myoung Sook Kim, Devulapalli Chakravarty, Fred E. Indig and France Carrier. (2009). Nucleolin Binds to the Proliferating Cell Nuclear Antigen and Inhibits Nucleotide Excision Repair. Molecular and Cellular Pharmacology 1, 130-137.

19. Xiaochen Wang, Jin Wang, Keiko Gengyo-Ando, Lichuan Gu, Chun-Ling Sun, Chonglin Yang, Yong Shi, Tetsuo Kobayashi, Yigong Shi,Shohei Mitani, Xiao-Song Xie & Ding Xue (2007). C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1. Nature Cell Biology 9, 541-549.

20. Chonglin Yang, Nieng Yan, Jay Parish, Xiaochen Wang, Yigong Shi and Ding Xue. (2006). RNA aptamers targeting the cell death inhibitor CED-9 induce cell killing in C. elegans. Journal of Biological Chemistry 281, 9137-9144.

   

发表专利

        专利名称:大豆胞囊线虫RNA解旋酶CGH-1及其编码基因与应用,专利号:ZL201110317555.5发  明 人:杨崇林,张劲松,陈受宜,李海潮,荆玉栋,蹇友理,李金英,王昉,李锦锦

专利名称:巨大戟醇及其衍生物在增强溶酶体生成中的应用,专利申请号:201610183289.4,发明人:杨崇林、郝小江、李洋、丁骁、徐猛、晏晨、邸迎彤、穆淑珍、蹇友理、宋智琴、郭伟翔

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